2,5-Thiophenedicarboxylic acid
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2,5-Thiophenedicarboxylic acid
- Name 2,5-Thiophenedicarboxylic acid
- CAS 4282-31-9
- Purity 99%
Product Details
Reputable factory supply 2,5-Thiophenedicarboxylic acid 4282-31-9 in stock with high standard
- Molecular Formula: C6H4O4S
- Molecular Weight: 172.161
- Appearance/Colour: white to light yellow crystal powder
- Vapor Pressure: 1.1E-08mmHg at 25°C
- Melting Point: >300 °C(lit.)
- Refractive Index: 1.5500 (estimate)
- Boiling Point: 444.6 °C at 760 mmHg
- PKA: 2.76±0.10(Predicted)
- Flash Point: 222.7 °C
- PSA： 102.84000
- Density: 1.655 g/cm3
- LogP: 1.14450
2,5-Thiophenedicarboxylic acid(Cas 4282-31-9) Usage
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Synthesis Reference(s) |
Journal of the American Chemical Society, 72, p. 2109, 1950 DOI: 10.1021/ja01161a065 |
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General Description |
2,5-Thiophenedicarboxylic acid (2,5-TDCA, H2TDC) is an important building block in the preparation of fluorescent brightening agent, fungicides and anti-cancer drug. It has been generated by chlorination of adipic acid using thionyl chloride. Due to its diverse coordination modes, it is an excellent choice as an aromatic linker to generate coordination networks. The enthalpies of combustion and sublimation of 2,5-thiophenedicarboxylic acid have been evaluated by rotary-bomb combustion calorimetry. |
InChI:InChI=1/C6H4O4S/c7-5(8)3-1-2-4(11-3)6(9)10/h1-2H,(H,7,8)(H,9,10)/p-2
4282-31-9 Relevant articles
METHOD FOR PRODUCING HETEROAROMATIC CARBOXYLIC ACID
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Paragraph 0039; 0041; 0042, (2018/08/09)
PROBLEM TO BE SOLVED: To provide a metho...
Preparation method of thiophene carboxyl-substituted derivative
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Paragraph 0074; 0076; 0078, (2018/05/07)
The invention provides a preparation met...
Preparation method of refined thiophene-2,5-dicarboxylic acid
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Paragraph 0020; 0021; 0022; 0023; 0024; 0025; 0026, (2017/12/30)
The invention provides a preparation met...
Preparation method of 2,5-thiophenedicarboxylic acid
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Paragraph 0022-0148, (2017/02/17)
The invention discloses a preparation me...
4282-31-9 Process route
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-
124-04-9
Adipic acid
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-
4282-31-9
Thiophene-2,5-dicarboxylic acid
| Conditions | Yield |
|---|---|
|
Adipic acid;
With
dmap; thionyl chloride;
at 78 - 81 ℃;
for 3.5h;
Large scale;
With
sodium hydroxide;
In
water;
at 70 - 72 ℃;
for 2h;
pH=9.3 - 10;
Reagent/catalyst;
Temperature;
pH-value;
Large scale;
|
75.58%
|
-
-
625-88-7
2,5-diiodothiophene
-
-
4282-31-9
Thiophene-2,5-dicarboxylic acid
| Conditions | Yield |
|---|---|
|
With
n-butyllithium; carbon dioxide;
In
tetrahydrofuran; water;
|
60%
|
|
With
diethyl ether; phenyllithium;
Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
|
4282-31-9 Upstream products
-
188290-36-0
thiophene
-
1822-71-5
n-pentylsodium
-
14593-46-5
sodium tert-pentoxide
-
15719-64-9
methylammonium carbonate
4282-31-9 Downstream products
-
3857-36-1
thiophene-2,5-dicarbonyl dichloride
-
128009-32-5
5-(trifluoromethyl)thiophene-2-carboxylic acid
-
87721-33-3
2,5-bis(trifluoromethyl)thiophene
-
2866-43-5
2,2'-thiophene-2,5-diylbis(benzoxazole)
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